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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

Online
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1865-7125
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Volume 64, Issue 7-8

Issues

DNA Damage and Repair of Head and Neck Cancer Cells after Radio- and Chemotherapy

Pawel Rusin
  • Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland. Fax: 0 04 84 26 35 44 84
  • Other articles by this author:
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/ Anna Walczak
  • Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland. Fax: 0 04 84 26 35 44 84
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/ Anita Zwierzchlejska
  • Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland. Fax: 0 04 84 26 35 44 84
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/ Jurek Olszewski / Alina Morawiec-Bajda / Dariusz Kaczmarczyk / Krzysztof Kusmierczyk / Pawel Garncarek
  • Department of Traumatic Orthopaedy, Ministry of Internal Affairs and Administration Hospital in Lodz,
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/ Dariusz Pytel / Tomasz Sliwinński
  • Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland. Fax: 0 04 84 26 35 44 84
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/ Ireneusz Majsterek
  • Corresponding author
  • Department of Molecular Genetics, University of Lodz, Banacha 12/16 Street, 90-237 Lodz, Poland. Fax: 0 04 84 26 35 44 84
  • Department of Chronopharmacology, Medical University of Lodz, Lodz, Poland
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2009-7-821

DNA repair is critical for successful chemo- and radiotherapy of human tumours, because their genotoxic sensitivity may vary in different types of cancer cells. In this study we have compared DNA damage and the efficiency of its repair after genotoxic treatment with hydrogen peroxide, cisplatin and γ-radiation of head and neck squamous cell carcinoma (HNSCC). Lymphocytes and tissue cells from biopsies of 37 cancer patients and 35 healthy donors as well as the HTB-43 larynx cancer cell line were employed. The cell sensitivity to genotoxic treatment was estimated by the MTT survival assay. The extent of DNA damage and efficiency of its repair was examined by the alkaline comet assay. Among the examined treatments, we found that HNSCC cells were the most sensitive to γ-radiation and displayed impaired DNA repair. In particular, DNA damage was repaired less effectively in cells from HNSCC metastasis than healthy controls. In conclusion, our results suggest that the different genotoxic sensitivity of HNSCC cells may depend on their DNA repair capacity what in turn may be connected with the effectiveness of head and neck cancer therapy.

Keywords: Head and Neck Cancer; DNA Damage; Comet Assay

About the article

Received: 2009-03-25

Revised: 2009-04-28

Published Online: 2014-06-02

Published in Print: 2009-08-01


Citation Information: Zeitschrift für Naturforschung C, Volume 64, Issue 7-8, Pages 601–610, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2009-7-821.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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