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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Volume 66, Issue 7-8

Issues

Pharmacological Activity of (R)-(+)-Pulegone, a Chemical Constituent of Essential Oils

Damião P. de Sousa
  • Department of Physiology, Federal University of Sergipe, CEP 49100–000, Aracaju, Sergipe, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Franklin F. F. Nóbrega
  • Laboratório de Tecnologia Farmacêutica, Federal University of Paraíba, Caixa Postal 5009, CEP 58051–970, João Pessoa, Paraíba, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maria R. V. de Lima
  • Laboratório de Tecnologia Farmacêutica, Federal University of Paraíba, Caixa Postal 5009, CEP 58051–970, João Pessoa, Paraíba, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Reinaldo N. de Almeida
  • Corresponding author
  • Laboratório de Tecnologia Farmacêutica, Federal University of Paraíba, Caixa Postal 5009, CEP 58051–970, João Pessoa, Paraíba, Brazil
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2011-7-806

(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a significant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also significantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.

Keywords: Essential Oils; Antinociceptive Activity; Analgesic

About the article

Received: 2010-04-24

Revised: 2011-03-10

Published Online: 2014-06-02

Published in Print: 2011-08-01


Citation Information: Zeitschrift für Naturforschung C, Volume 66, Issue 7-8, Pages 353–359, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2011-7-806.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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