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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

12 Issues per year


IMPACT FACTOR 2016: 0.835

CiteScore 2016: 0.72

SCImago Journal Rank (SJR) 2016: 0.222
Source Normalized Impact per Paper (SNIP) 2016: 0.413

Online
ISSN
1865-7125
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Volume 67, Issue 1-2

Issues

Evaluation of the Anti-Inflammatory and Antinociceptive Properties of p-Cymene in Mice

Leonardo R. Bonjardim
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  • Department of Physiology, Universidade Federal de Sergipe (DFS/UFS), Aracaju, SE, Brazil. Fax: (0055) 79-2105-6494
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/ Edisleide S. Cunha
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/ Adriana G. Guimarães
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/ Michele F. Santana
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/ Makson G. B. Oliveira
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/ Mairim R. Serafini
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/ Adriano A. S. Araújo
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/ Ângelo R. Antoniolli
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/ Sócrates C. H. Cavalcanti
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/ Márcio R. V. Santos
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/ Lucindo J. Quintans-Júnior
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2012-1-203

We attempted to identify the antinociceptive and anti-inflammatory actions of the monoterpene p-cymene. Firstly, behavioural screening was carried out to verify the influence of p-cymene [25, 50, and 100 mg/kg intraperitoneal (i.p.)] on the central nervous system (CNS) activity. The antinociceptive activity of p-cymene was evaluated by the acetic acidinduced writhing response, formalin, and hot-plate test, respectively. The leukocyte migration induced by injection of carrageenan was used to assess the anti-inflammatory activity. p-Cymene showed depressant activity on CNS after 4 h of treatment and also a possible action on the autonomous nervous system (ANS), mainly at the dose of 100 mg/kg (i.p.). It was found that p-cymene (50 and 100 mg/kg, i.p.) significantly (p < 0.05) reduced the writhing responses induced by acetic acid. p-Cymene also decreased the licking time in the first and second phase, respectively, of the formalin test. The results of the hot-plate test showed that all doses of p-cymene increased significantly the latency time of the response to the thermal stimulus in both licking and jumping parameters. In addition, there was a significantly (p < 0.05) decreased leukocyte migration at all doses of p-cymene. The experimental data demonstrate that p-cymene possesses antinociceptive and anti-inflammatory activities

Keywords: Monoterpene; p-Cymene; Pain; Inflammation

About the article

Received: 2011-03-11

Revised: 2011-11-21

Published Online: 2014-06-02

Published in Print: 2012-02-01


Citation Information: Zeitschrift für Naturforschung C, Volume 67, Issue 1-2, Pages 15–21, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2012-1-203.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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