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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Potent Antifungal and Antistaphylococcal 2-Anilinobenzimidazoles

  • Hakan Göker EMAIL logo , Cigdem Karaaslana and Sulhiye Yıldız

A series of 21 anilinobenzimidazoles with a 2,4-difluorophenyl group were synthesized and their minimum inhibitory concentrations (MIC) determined by the tube dilution method. Most of the compounds exhibited excellent MIC values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Among them, compound 27 having dibromo substitution at the 4- and 6-position of the benzimidazole ring showed the best antifungal activity against Candida krusei with a MIC value of 3.12 μg/mL that surpassed that of the reference drug fl uconazole

Received: 2011-11-15
Revised: 2012-4-15
Published Online: 2014-6-2
Published in Print: 2012-10-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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