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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

Online
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1865-7125
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Volume 69, Issue 3-4

Issues

Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella

Seif-Eldin N. Ayyad
  • Corresponding author
  • Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Fax: +966 2 6951599.
  • Permanent address: Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rihab Angawy
  • Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Fax: +966 2 6951599.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alarif
  • Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah 21589, Saudi Arabia
  • Forensic Chemistry Laboratory at Mansoura, Ministry of Justice, Mansoura, Egypt
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Esraa A. Saqer
  • Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Fax: +966 2 6951599.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Farid A. Badria
Published Online: 2014-06-02 | DOI: https://doi.org/10.5560/znc.2013-0088

Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11:7 mM, respectively.

Keywords : Red Sea; Marine Sponges; Breast Cancer

About the article

Received: 2013-05-05

Revised: 2014-01-25

Published Online: 2014-06-02

Published in Print: 2014-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 69, Issue 3-4, Pages 117–123, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.5560/znc.2013-0088.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung.

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John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro, and Michèle R. Prinsep
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