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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Volume 69, Issue 3-4

Issues

Antileishmanial Compounds from Moringa oleifera Lam.

Amandeep Kaur
  • Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India. Fax: +91-172-2214692.
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/ Preet Kamal Kaur
  • Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India
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/ Sushma Singh
  • Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India
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/ Inder Pal Singh
  • Corresponding author
  • Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160062, India. Fax: +91-172-2214692.
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Published Online: 2014-06-02 | DOI: https://doi.org/10.5560/znc.2013-0159

The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam: was investigated in vitro against promastigotes of Leishmania donavani. The 70%ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of 83:0 μg/ml and 47:5 μg/ml, respectively. Antileishmanial activity of the methanolic extract of leaves increased upon fractionation, as its ethyl acetate fraction was found to be more active with an IC50 value of 27:5 mg=ml. The most active antileishmanial compound niazinin, a thiocarbamate glycoside isolated from this fraction, showed an IC50 value of 5:25 mM. Results presented in this study indicate that extracts from M. oleifera may be developed as an adjuvant therapy for the treatment of leishmaniasis.

Keywords : Leishmaniasis; Moringa oleifera; Promastigotes; Thiocarbamate Glycosides

About the article

Received: 2013-09-22

Revised: 2013-11-08

Published Online: 2014-06-02

Published in Print: 2014-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 69, Issue 3-4, Pages 110–116, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.5560/znc.2013-0159.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung.

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