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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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Volume 70, Issue 3-4

Issues

Differential cytotoxic activity of the petroleum ether extract and its furanosesquiterpenoid constituents from Commiphora molmol resin

Seif-Eldin N. Ayyad
  • Corresponding author
  • Faculty of Science, Department of Chemistry, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA
  • Faculty of Science, Chemistry Department, Damietta University, Damietta 34511, Egypt
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Thomas R. Hoye
  • Departments of Chemistry and Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
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  • De Gruyter OnlineGoogle Scholar
/ Walied M. Alarif
  • Faculty of Marine Sciences, Department of Marine Chemistry, King Abdulaziz University, P.O. 80207, Jeddah 21589, KSA
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/ Sana’a M. Al Ahmadi
  • Faculty of Science, Chemistry Department, Taibah University, Al-Madinah Al-Munawarah, P.O. 30100, KSA
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/ Salim A. Basaif
  • Faculty of Science, Department of Chemistry, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA
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/ Mohamed A. Ghandourah
  • Faculty of Marine Sciences, Department of Marine Chemistry, King Abdulaziz University, P.O. 80207, Jeddah 21589, KSA
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/ Farid A. Badria
Published Online: 2015-05-28 | DOI: https://doi.org/10.1515/znc-2014-4191

Abstract

This study revealed a differential cytotoxic activity of the petroleum ether extract (IC50=5 μg/mL) of the resinous exudates of Commiphora molmol against two mouse cell lines KA31T and NIH3T3 (untransformed and transformed mouse fibroblasts, respectively). Four new compounds (14) and five known compounds (59) were isolated from the petroleum ether extract. The identity of these new compounds was determined as γ-elemane lactone (1), 5-αH,8-βH-eudesma-1,3,7(11)-trien-8,12-olide (2), 2-hydroxy-11,12-dihydrofuranodiene (3), and 2-hydroxyfuranodiene (4). 1 and 2 displayed the highest cytotoxic activity against NIH3T3 cells. 7 and 9 exhibited moderate cytotoxic activity against KA31T cells. Compounds 36 showed weak cytotoxic activities against both cell lines. These results may explain the high efficacy of the petroleum ether fraction in several myrrh-derived pharmaceutical preparations.

Keywords: cytotoxicity; KA31T; myrrh resin; NIH3T3; sesquiterpenoids

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About the article

Corresponding author: Seif-Eldin N. Ayyad, Faculty of Science, Department of Chemistry, King Abdulaziz University, P.O. 80203, Jeddah 21589, KSA; and Faculty of Science, Chemistry Department, Damietta University, Damietta 34511, Egypt, E-mail:


Received: 2014-11-05

Revised: 2014-12-17

Accepted: 2015-04-26

Published Online: 2015-05-28

Published in Print: 2015-03-01


Citation Information: Zeitschrift für Naturforschung C, Volume 70, Issue 3-4, Pages 87–92, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2014-4191.

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