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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Volume 70, Issue 3-4

Issues

A novel C25 sterol peroxide from the endophytic fungus Phoma sp. EA-122

Zi-Ming Chen
  • School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Qiong-Ying Fan / He-Ping Chen
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • University of Chinese Academy of Sciences, Beijing, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zheng-Hui Li
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tao Feng
  • Corresponding author
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ji-Kai Liu
  • Corresponding author
  • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
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Published Online: 2015-03-31 | DOI: https://doi.org/10.1515/znc-2014-4217

Abstract

A novel C25 sterol peroxide, phomasterol A (1), together with two known compounds (23), was isolated from the endophytic fungus Phoma sp. EA-122. The structure of phomasterol A (1) was elucidated by MS, 1D, and 2D NMR data analyses. Phomasterol A (1) was evaluated for its inhibitory activities against protein-tyrosine phosphatases MEG2 and PTP1Bc, showing moderate activities with identical IC50 values of 25 μM.

Keywords: C25 sterol peroxide; endophytic fungus; Phoma sp.; protein-tyrosine phosphatase

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About the article

Corresponding authors: Tao Feng and Ji-Kai Liu, 132# Lanhei Road, Heilongtan, Kunming 650201, Yunnan, P. R. China, Tel.: +86 871 65216327, Fax: +86 871 65212285, E-mail: , ; and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China


Received: 2014-12-22

Revised: 2015-02-27

Accepted: 2015-03-04

Published Online: 2015-03-31

Published in Print: 2015-03-01


Citation Information: Zeitschrift für Naturforschung C, Volume 70, Issue 3-4, Pages 93–96, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2014-4217.

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