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Licensed Unlicensed Requires Authentication Published by De Gruyter August 13, 2016

Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species

  • Samar S.A. Mourshid , Jihan M. Badr , April L. Risinger , Susan L. Mooberry and Diaa T.A. Youssef EMAIL logo

Abstract

Two new antimicrobial fatty acid esters, penicilloitins A and B (1 and 2), along with α-cyclopiazonic acid (3), tryptamine (4) and indole-3-carbaldehyde (5), were isolated from mycelial extracts and the culture broth of a marine endophytic Penicillium species and their structures established by spectroscopic techniques including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, multiplicity-edited HSQC, and HMBC) as well as HRESIMS. Of these compounds, 1, 3 and 4 displayed modest antimicrobial activity.

Acknowledgement

This project was supported by the NSTIP strategic technologies program in the Kingdom of Saudi Arabia, project no. 11-BIO1556-03. The authors also gratefully acknowledge the Science and Technology Unit, King Abdulaziz University, for technical support.

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Received: 2015-10-17
Revised: 2016-4-5
Accepted: 2016-7-9
Published Online: 2016-8-13
Published in Print: 2016-11-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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