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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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1865-7125
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Volume 71, Issue 7-8

Issues

Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)

Juliane C. Silva
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Larissa A.R.O. Macedo
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Grasielly R. Souza
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Raimundo G. Oliveira-Junior
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Sarah R.G. Lima-Saraiva
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Érica M. Lavor
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Mariana G. Silva
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Marilia T.S. Souza
  • Department of Physiology, Federal University of Sergipe (DFS/UFS), Postal Code 49.100-000, São Cristóvão, Sergipe, Brazil
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/ Leonardo R. Bonjardim
  • Department of Physiology, Federal University of Sergipe (DFS/UFS), Postal Code 49.100-000, São Cristóvão, Sergipe, Brazil
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/ Lucindo J. Quintans-Júnior
  • Department of Physiology, Federal University of Sergipe (DFS/UFS), Postal Code 49.100-000, São Cristóvão, Sergipe, Brazil
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/ Rosemairy L. Mendes
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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/ Jackson R.G.S. Almeida
  • Corresponding author
  • Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Postal Code 56.304-205, Petrolina, Pernambuco, Brazil
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Published Online: 2016-06-07 | DOI: https://doi.org/10.1515/znc-2015-5024

Abstract

Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as “araticum” and “pinha da Caatinga”. We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.

Keywords: Annona vepretorum; antinociceptive; orofacial pain

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About the article

Received: 2015-02-20

Revised: 2016-04-26

Accepted: 2016-04-26

Published Online: 2016-06-07

Published in Print: 2016-07-01


Citation Information: Zeitschrift für Naturforschung C, Volume 71, Issue 7-8, Pages 209–214, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2015-5024.

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