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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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IMPACT FACTOR 2017: 0.882
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1865-7125
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Volume 72, Issue 1-2

Issues

Simultaneous formulation of terbinafine and salvia monoterpenes into chitosan hydrogel with testing biological activity of corresponding dialysates against C. albicans yeast

Alexandra Kodadová
  • Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
  • Other articles by this author:
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/ Zuzana Vitková
  • Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
  • Other articles by this author:
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/ Jarmila Oremusová
  • Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
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  • De Gruyter OnlineGoogle Scholar
/ Petra Herdová
  • Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
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  • De Gruyter OnlineGoogle Scholar
/ Anton Ťažký
  • Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
  • Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic
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/ Peter Mikuš
  • Corresponding author
  • Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovak Republic
  • Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic, Phone: 421-2-50 117 243
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  • Other articles by this author:
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Published Online: 2016-10-22 | DOI: https://doi.org/10.1515/znc-2016-0161

Abstract

This work was aimed at a progressive formulation of drugs into chitosan hydrogels. It was taken into consideration that a therapeutic effect of the drugs could be enhanced by a combination of natural compounds with chemical (synthetic) drugs. In this work, sage essential oil (SEO) bicyclic monoterpenes with antiflogistic, antiseptic, and antimycotic properties were combined with terbinafine (TB) having a strong antimycotic activity. Detail optimization of the hydrogel-drugs composition (SEO monoterpenes, TB, chitosan, and polysorbate 80 concentrations), based on permeation experiment and UV absorption/GC-MS analysis of permeated species (eucalyptol, camphor, borneol, thujone, TB) in dialysates, was made. Concerning the active drugs formulation, an optimum concentration of TB was set at the level providing maximum release of the SEO monoterpenes. In vitro activity of the dialysates from the optimized hydrogel was tested against Candida albicans showing that a minimum inhibition concentration was significantly exceeded. The experimental results revealed that the chitosan hydrogel was suitable for the simultaneous formulation of the natural drugs (SEO) with chemical drug (TB) resulting in the preparation with acceptable stability, required gel properties, and significant biological activity. Such preparation should be effective in an antimycotic dermal use.

Keywords: antimycotic activity; chitosan hydrogels; permeation experiment; sage essential oil monoterpenes (Salvia monoterpenes); terbinafine

References

  • 1.

    European Pharmacopoeia8.0(PhEur 8.0) Vol. 1 Council of Europe. Strasbourg 01/2014, 809 ISBN: 978-92-871-7525-0.Google Scholar

  • 2.

    Chalupova Z, Masteikova R, Savickas A. Pharmaceutical hydrophilic gels. Ces Slov Farm 2005;54:55–8.Google Scholar

  • 3.

    Komarek P, Rabiskova M. Technology of drugs, 1st ed. Prague: Galen, 2006.Google Scholar

  • 4.

    Alssara IA. Chitosan topical gel formulation in the management of burn wounds. Int J Biol Macromol 2009;45:16–21.CrossrefWeb of ScienceGoogle Scholar

  • 5.

    Herdova P, Vitkova Z. Liberation study of drugs from chitosan hydrogels. Derma 2010;10:20–3.Google Scholar

  • 6.

    Vitkova Z, Oremusova J, Herdova P, Kodadova A. Release and rheological properties of topical drugs. Tenside Surfact Det 2013;50:39–44.CrossrefGoogle Scholar

  • 7.

    Matusova D, Truplova E. Drugs and preparations for the treatment of burns. Ces Slov Farm 2006;55:51–4.Google Scholar

  • 8.

    Kodadova A, Vitkova Z, Herdova P, Tazky A, Oremusova J, Grancai D, et al. Formulation of sage essential oil (Salvia officinalis, L.) monoterpenes into chitosan hydrogels and permeation study with GC-MS analysis. Drug Dev Ind Pharm 2015;41:1080–8.CrossrefWeb of ScienceGoogle Scholar

  • 9.

    Badiee P, Nasirzadeh AR, Motaffaf M. Comparison of Salvia officinalis, L. essential oil and antifungal agents against Candida species. J Pharm Technol Drug Res 2012;1:7–12.CrossrefGoogle Scholar

  • 10.

    Vollekova A. Antimycotics in dermatology. Dermatologia pre prax 2012;6:152–7.Google Scholar

  • 11.

    Koc AN, Gokahmetoglu S. In vitro activities of terbinafine compared with those of amphotericin B and azoles against clinical Candida isolates. J Antimicrob Chemother 2000;14:111–5.Google Scholar

  • 12.

    Ghannoum MA, Welshenbaugh A, Imamura Y, Isham N, Mallefet P, Yamaguchi H. Comparison of the in vitro activity of terbinafine and lanoconazole against dermatophytes. Mycoses 2010;53:311–3.Web of ScienceGoogle Scholar

  • 13.

    Ryder NS, Wagner S, Leintner I. In vitro activities of terbinafine against cutaneous isolates of Candida albicans and other pathogenic yeasts. Antimicrob Agents Chemother 1998;42:1057–61.Google Scholar

About the article

Received: 2016-08-10

Revised: 2016-09-20

Accepted: 2016-09-24

Published Online: 2016-10-22

Published in Print: 2017-01-26


Citation Information: Zeitschrift für Naturforschung C, Volume 72, Issue 1-2, Pages 63–69, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2016-0161.

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