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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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Volume 72, Issue 5-6


Aspernolides L and M, new butyrolactones from the endophytic fungus Aspergillus versicolor

Sabrin R.M. Ibrahim
  • Corresponding author
  • Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia, Phone: +966 581183034, E-mail:
  • Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gamal A. Mohamed
  • Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Samir A. Ross
  • National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Mississippi 38677, United States of America
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-09-21 | DOI: https://doi.org/10.1515/znc-2016-0138


During the systematic search of active compounds from endophytic fungi, two new butyrolactones, namely aspernolides L (2) and M (4), together with four known compounds: 1-O-acetylglycerol (1), butyrolactone I (3), butyrolactone VI (5), and (+) alantrypinone (6) were characterized from the EtOAc extract of the endophytic fungus Aspergillus versicolor isolated from the roots of Pulicaria crispa (Asteraceae). Extensive spectroscopic analysis, including 1D, 2D NMR, and HRESIMS, was used to elucidate their structures. Compounds 1, 5, and 6 are reported for the first time from this fungus.

This article offers supplementary material which is provided at the end of the article.

Keywords: Aspergillus versicolor; Aspernolide; butyrolactones; endophytic fungi; Pulicaria crispa


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About the article

Received: 2016-06-30

Revised: 2016-08-28

Accepted: 2016-08-30

Published Online: 2016-09-21

Published in Print: 2017-05-01

Citation Information: Zeitschrift für Naturforschung C, Volume 72, Issue 5-6, Pages 155–160, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2016-0138.

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