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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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1865-7125
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Volume 74, Issue 9-10

Issues

Aromatase (CYP19) inhibition by biflavonoids obtained from the branches of Garcinia gardneriana (Clusiaceae)

Angelica Maria Recalde-Gil
  • Laboratório de Farmacognosia e Controle de Qualidade de Fitoterápicos, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
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/ Luiz Klein-JúniorORCID iD: https://orcid.org/0000-0003-2243-1701
  • Corresponding author
  • Laboratório de Farmacognosia e Controle de Qualidade de Fitoterápicos, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
  • Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí – UNIVALI, Rua Uruguai, 458 – 88302-202, Itajaí/SC, Brazil
  • orcid.org/0000-0003-2243-1701
  • Email
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/ Juliana Salton
  • Laboratório de Farmacognosia e Controle de Qualidade de Fitoterápicos, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
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/ Sérgio Bordignon
  • Laboratório de Conservação da Biodiversidade e Manejo, Universidade La Salle, Canoas 92010-000, Brazil
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/ Valdir Cechinel-Filho
  • Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Itajaí 88302-901, Brazil
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/ Cristiane Matté
  • Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
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/ Amélia Henriques
  • Laboratório de Farmacognosia e Controle de Qualidade de Fitoterápicos, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, Brazil
  • Other articles by this author:
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Published Online: 2019-08-06 | DOI: https://doi.org/10.1515/znc-2019-0036

Abstract

Overexpression of aromatase in breast cancer cells may substantially influence its progression and maintenance. In this sense, the inhibition of aromatase is a key target for the treatment of breast cancer in postmenopausal women. Although several flavonoids had already demonstrated the capacity of inhibiting aromatase activity, the role of biflavonoids as aromatase inhibitors is poorly studied. In this work, the biflavonoids isolated from Garcinia gardneriana, morelloflavone (1), Gb-2a (2) and Gb-2a-7-O-glucose (3) were submitted to in vitro assay to evaluate the aromatase modulatory effect. As results, it was demonstrated that all biflavonoids were able to inhibit the enzyme, with IC50 values ranging from 1.35 to 7.67 μM. This demonstrates that biflavonoids are an important source of scaffolds for the development of new aromatase inhibitors, focusing on the development of new anticancer agents.

Keywords: aromatase; bioflavonoids; CYP19; Garcinia gardneriana

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About the article

Received: 2019-02-07

Revised: 2019-05-03

Accepted: 2019-06-13

Published Online: 2019-08-06

Published in Print: 2019-09-25


Citation Information: Zeitschrift für Naturforschung C, Volume 74, Issue 9-10, Pages 279–282, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2019-0036.

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