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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Antimalarial activity of the isolates from the marine sponge Hyrtios erectus against the chloroquine-resistant Dd2 strain of Plasmodium falciparum

Eunsin Ju
  • Division of Marine Bioscience, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
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/ Abdul Latif
  • Department of Chemistry, University of Malakand, Chakdara 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan
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/ Chang-Suk KongORCID iD: http://orcid.org/0000-0002-2304-9304 / Youngwan Seo
  • Corresponding author
  • Division of Marine Bioscience, Korea Maritime and Ocean University, Busan 49112, Republic of Korea
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/ Yeon-Ju Lee
  • Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 15627, Republic of Korea
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/ Seema R. Dalal
  • Department of Biochemistry and Virginia Tech Center for Drug Discovery, M/C 0308, Virginia Tech, Blacksburg, VA 24061, USA
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/ Maria B. Cassera
  • Department of Biochemistry and Virginia Tech Center for Drug Discovery, M/C 0308, Virginia Tech, Blacksburg, VA 24061, USA
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/ David G.I. Kingston
  • Department of Chemistry and the Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, USA
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Published Online: 2018-05-29 | DOI: https://doi.org/10.1515/znc-2018-0025

Abstract

This work reports the isolation of the three known compounds, smenotronic acid (1), ilimaquinone (2), and pelorol (3), from the 85% methanol (MeOH)-soluble fraction of the sponge Hyrtios erectus. The structures of the isolated compounds were determined with the help of modern spectroscopic techniques, and the resulting compounds were then subjected to in vitro screening to determine their antimalarial potential against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. Amongst the three compounds, pelorol (3) showed significant activity against P. falciparum with an IC50 value of 0.8 μM. For smenotronic acid (1) and ilimaquinone (2), moderate activities were observed with IC50 values of 3.51 and 2.11 μM, respectively.

Keywords: antimalarial activity; Hyrtios erectus; ilimaquinone; pelorol; smenotronic acid

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About the article

Received: 2018-02-11

Revised: 2018-04-21

Accepted: 2018-04-30

Published Online: 2018-05-29


Citation Information: Zeitschrift für Naturforschung C, 20180025, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2018-0025.

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