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Cyproheptadine, an antihistaminic and antipruritic drug, forms fairly stable charge-transfer complexes with quinone (Q), chloranil (Chl-Q) and anthraquinone (AQ) in chloroform. It also forms stable hydrogen bonds with alcohols (methanol and propanol) and phenols (α-naphthol, p-cresol and p-chlorophenol). A rough correlation has been observed with log K of hydrogenbonded complexes with pK-values of phenols.
The results suggest that cyproheptadine can form loose association with receptors through charge-transfer and hydrogen bond complex formation.
Published Online: 2009-09-25
Published in Print: 2001-07