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Zeitschrift für Physikalische Chemie

International journal of research in physical chemistry and chemical physics

Editor-in-Chief: Rademann, Klaus

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CiteScore 2018: 1.20

SCImago Journal Rank (SJR) 2018: 0.327
Source Normalized Impact per Paper (SNIP) 2018: 0.391

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Volume 227, Issue 4


Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study

Wajid Husain Ansari / Sahar Noori / Andleeb Naqvi / Kabir - ud - Din
Published Online: 2013-01-28 | DOI: https://doi.org/10.1524/zpch.2012.0340


The physicochemical properties, viz, critical micelle concentration (cmc), surface excess concentration (Γmax), minimum area per head group (Amin) of zwitterionic surfactants (designated as n(−)-2-m(+); n = 8, 10, 12 and m = 12, 14, 16) and their mixtures with amphiphilic antidepressant drug amitriptyline hydrochloride (AMT) were determined by using surface tension measurements. The cmc and ideal cmc (cmcid) values along with interaction parameters, βm and βσ (calculated using Rubingh's and Rosen's models), suggest attractive interactions among the components. The Krafft temperature measurements also indicate strong attractive interactions. Γmax (or Amin) increases (or decreases) with the addition of gemini surfactant; the values being closer to that of the drug. These values and micellar mole fraction (X1m-calculated from Rubingh's model and X1Moto-calculated from Motomura's model) indicate larger contribution of gemini surfactants in mixed micelles and smaller contribution at air/solution interface (as mole fraction values at interface, X1σ, are slightly smaller than X1m). The standard Gibbs energy of micellization (Δ Gmicº) and adsorption (Δ Gadº) as well as excess energy of mixing (Δ Gexm) are all negative. All these results suggest higher stability of the mixed systems. UV absorbance results also suggest that the mixed micelles are stable for several days.

Keywords: Amitriptyline Hydrochloride; Zwitterionic Gemini Surfactants; Surface Tension; Mixed Micelles

About the article

* Correspondence address: Aligarh Muslim University, Department of Chemistry, Aligarh-202002, Indien,

Published Online: 2013-01-28

Published in Print: 2013-04-01

Citation Information: Zeitschrift für Physikalische Chemie, Volume 227, Issue 4, Pages 441–458, ISSN (Online) 2196-7156, ISSN (Print) 0942-9352, DOI: https://doi.org/10.1524/zpch.2012.0340.

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