Cellular membranes contain many types and species of
lipids. One of the most important functional consequences of this heterogeneity
is the existence of microdomains within the plane of the membrane. Sphingolipid
acyl chains have the ability of forming tightly packed platforms together with
sterols. These platforms or lipid rafts constitute segregation and sorting
devices into which proteins specifically associate. In budding yeast,
Saccharomyces cerevisiae, lipid rafts serve as sorting platforms for proteins
destined to the cell surface. The segregation capacity of rafts also provides
the basis for the polarization of proteins at the cell surface during mating.
Here we discuss some recent findings that stress the role of lipid rafts as key
players in yeast protein sorting and cell polarity.
Biological Chemistry keeps you up-to-date with the latest advances in the molecular life sciences. The journal publishes Research Articles, Short Communications, Reviews and Minireviews. Areas include: general biochemistry/pathobiochemistry, structural biology, molecular and cellular biology, genetics and epigenetics, virology, molecular medicine, plant molecular biology/biochemistry and novel experimental methodologies.