Adaptation to oxidative and nitrosative stress occurs
in cells first exposed to a nontoxic stress, resulting in
the ability to tolerate a toxic challenge of the same or
a related oxidant. Adaptation is observed in a wide
variety of cells including endothelial cells on exposure
to nitric oxide or oxidized lipids, and lung epithelial
cells exposed to air-borne pollutants and toxicants.
This acquired characteristic has been related
to the regulation of a family of stress responding proteins
including those that control the synthesis of the
intracellular antioxidant glutathione. The focus of this
article, which includes a review of recent results
along with new data, is the regulation and signaling of
glutathione biosynthesis, especially those relating to
adaptive mechanisms. These concepts are illustrated
with examples using nitric oxide and oxidized low
density lipoprotein mediated adaptation to oxidative
stress. These data are discussed in the context of
other adaptive mechanisms relating to glutathione
synthesis including those from dietary constituents
such as curcumin.
Biological Chemistry keeps you up-to-date with the latest advances in the molecular life sciences. The journal publishes Research Articles, Short Communications, Reviews and Minireviews. Areas include: general biochemistry/pathobiochemistry, structural biology, molecular and cellular biology, genetics and epigenetics, virology, molecular medicine, plant molecular biology/biochemistry and novel experimental methodologies.