Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers

Milton R. Moraes 1 , 1 , Reury F.P. Bacurau 2 , 2 , João D.S. Ramalho 3 , 3 , Felipe C.G. Reis 4 , 4 , Dulce E. Casarini 5 , 5 , Jair R. Chagas 6 , 6 , Vitor Oliveira 7 , 7 , Elisa Mieko S. Higa 8 , 8 , Dulcinéia S.P. Abdalla 9 , 9 , Jorge L. Pesquero 10 , 10 , João B. Pesquero 11 , 11  and Ronaldo C. Araujo 12 , 12
  • 1 Department of Biophysics, Federal University of São Paulo, CEP 04023-062 São Paulo, Brazil and Laboratory of Fitness and Health, University of Mogi das Cruzes, CEP 08780-911 São Paulo, Brazil
  • 2 School of Nutrition, Faculdades Metropolitanas Unidas, CEP 01506-000 São Paulo, Brazil
  • 3 Laboratory of Fitness and Health, University of Mogi das Cruzes, CEP 08780-911 São Paulo, Brazil
  • 4 Department of Biophysics, Federal University of São Paulo, CEP 04023-062 São Paulo, Brazil
  • 5 Nephrology Division, Federal University of São Paulo, CEP 04023-900 São Paulo, Brazil
  • 6 Federal University of São Paulo, CEP 11060-001 Santos, Brazil
  • 7 Department of Biophysics, Federal University of São Paulo, CEP 04023-062 São Paulo, Brazil
  • 8 Nephrology Division, Federal University of São Paulo, CEP 04023-900 São Paulo, Brazil
  • 9 Faculty of Pharmaceutical Sciences, University of São Paulo, CEP 05508-900 São Paulo, Brazil
  • 10 Laboratory of Fitness and Health, University of Mogi das Cruzes, CEP 08780-911 São Paulo, Brazil and Department of Physiology and Biophysics, Federal University of Minas Gerais, CEP 30270-901 Belo Horizonte, Brazil
  • 11 Department of Biophysics, Federal University of São Paulo, CEP 04023-062 São Paulo, Brazil
  • 12 Department of Biophysics, Federal University of São Paulo, CEP 04023-062 São Paulo, Brazil

Abstract

Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear. The kallikrein-kinin system is involved in blood pressure control, but its role in post-exercise hypotension has not yet been investigated. Thus, the purpose of this study was to investigate the involvement of the vasodilators bradykinin and des-Arg9-BK and kallikrein activity in post-exercise hypotension promoted by 35 min of cycle ergometer (CE) or circuit weight-training (CWT) bouts in normotensive and hypertensive individuals. A significant decrease in mean arterial pressure at 45 and 60 min after CE and 45 min after CWT was observed in normotensive individuals. Hypertensive values of mean arterial pressure were significantly reduced at 45 and 60 min after CE and at 60 min after CWT. Before exercise, plasma bradykinin concentrations and kallikrein activity were higher in hypertensive compared to normotensive volunteers. Kinin levels increased in the groups evaluated at the end of the training period and 60 min post-exercise. These data suggest that the kallikrein-kinin system may be involved in post-exercise hypotension in normotensive and hypertensive individuals subjected to CE and CWT bouts.

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Biological Chemistry keeps you up-to-date with the latest advances in the molecular life sciences. The journal publishes Research Articles, Short Communications, Reviews and Minireviews. Areas include: general biochemistry/pathobiochemistry, structural biology, molecular and cellular biology, genetics and epigenetics, virology, molecular medicine, plant molecular biology/biochemistry and novel experimental methodologies.

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