Potential biomarkers of ageing

Andreas Simm 1 , 1 , Norbert Nass 2 , 2 , Babett Bartling 3 , 3 , Britt Hofmann 4 , 4 , Rolf-Edgar Silber 5 , 5  and Alexander Navarrete Santos 6 , 6
  • 1 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
  • 2 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
  • 3 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
  • 4 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
  • 5 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany
  • 6 Department of Cardiothoracic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle, Germany

Abstract

Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation, inflammation, cellular senescence and hormonal deregulation are discussed.

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Biological Chemistry keeps you up-to-date with the latest advances in the molecular life sciences. The journal publishes Research Articles, Short Communications, Reviews and Minireviews. Areas include: general biochemistry/pathobiochemistry, structural biology, molecular and cellular biology, genetics and epigenetics, virology, molecular medicine, plant molecular biology/biochemistry and novel experimental methodologies.

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