New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L.

Mukunda Chethankumar 1 , 1  and Leela Srinivas 2 , 2
  • 1 Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India
  • 2 Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India

Abstract

Turmerin is a protein from Turmeric (Curcuma longa L.) with a relative molecular mass of 14 kDa. The protein inhibits the enzymatic activity and neutralises the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase A2 (NV-PLA2) of cobra (Naja naja) venom at a 1:2.5 molar ratio of NV-PLA2:Turmerin. A Lineweaver-Burk plot indicates that Turmerin follows a linear mixed type of inhibition.

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Biological Chemistry keeps you up-to-date with the latest advances in the molecular life sciences. The journal publishes Research Articles, Short Communications, Reviews and Minireviews. Areas include: general biochemistry/pathobiochemistry, structural biology, molecular and cellular biology, genetics and epigenetics, virology, molecular medicine, plant molecular biology/biochemistry and novel experimental methodologies.

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