Recently, sol-gel derived borate glasses (BGs)
have shown unprecedented conversion rates to bone-like
mineral (hydroxycarbonated apatite). In an effort to explore
their potential applications in bone tissue engineering,
this study reports on the fabrication and characterization
of BG particle incorporated electrospun "-
polycaprolactone (PCL) fibrous composites. The electrospinning
technique successfully incorporated PCL fibres
with BG particles at 2.5 and 5 w/v%, with the higher
BG loading creating a three-dimensional cotton-wool like
morphology. Dynamic vapour sorption showed greater extents
of mass change with BG content attributable to water
sorption, and indicating greater reactivity in the composite
systems. In vitro bioactivity was investigated in simulated
body fluid for up to 7 days. Scanning electron microscopy,
Fourier-transform infrared spectroscopy and xray
diffraction indicated apatite formation in the 5 w/v%
incorporated composite scaffold, which initiated as early
as day 3. In summary, sol-gel derived BGs incorporatedfibrous
electrospun PCL composites indicate rapid reactivity
and bioactivity with potential applications in mineralized
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Biomedical Glasses is an international open access journal covering the field of glasses for biomedical applications. The aim of the journal is to provide a peer-reviewed forum for the publication of original research reports and authoritative review articles related to the development of biomedical glasses and their use in clinical applications.