Evolutionary mechanisms of circadian clocks

Guillermo Rodrigo 1 , Javier Carrera 1  and Alfonso Jaramillo 2
  • 1 Depto. de Matematica Aplicada, Universidad Politecnica de Valencia, 46022, Valencia, Spain
  • 2 CNRS — UMR 7654, Ecole Polytechnique, Laboratoire de Biochimie, 91128, Palaiseau, France


An intriguing question in biology is to know how circadian molecular networks could have evolved their particular topologies to adjust to a daily period. We analyze the mechanism of the evolution of such networks by using a computational design strategy that allows for the generation of synthetic networks with a targeted 24 hours oscillation. We have performed a systematic analysis of all possible two-gene network topologies based on a core activator-repressor frequently found in circadian mechanisms. We have considered transcriptional and post-translational regulations to implement this core. We have applied our analysis to both, eukaryotic and prokaryotic circadian machinery. Finally, we conjecture a possible mechanism for the evolution of circadian clocks.

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