The bacterial translocation induced by colitis may cause the organ failure and sepsis. Therefore, it is necessary to find new possibilities for prevention and therapy of this problem. The purpose of this study was to examine Escherichia coli anti-translocation activity of cinnamon oil and its ability to reduce colonic damage in mice with TNBS (2,4,6-trinitrobenzenesulfonic acid) induced colitis. Mice received cinnamon essential oil in four various concentrations (0.5%, 0.25%, 0.125% and 0.063%) in the powdery commercial rodent diet, starting 21 days before induction of TNBS colitis. The colonic damage was assessed using the colon macroscopic scoring system (Wallace score). E. coli translocation to the mesenteric lymphatic nodules was evaluated by serial dilutions method for counting bacteria. Bacterial translocation was significantly reduced in first and third group (15.2% or 42.8% in cinnamon oil groups versus 100% in TNBS group). Cinnamon oil was effective also against the colonic damage in all cinnamon oil groups (macroscopically scores of grade 9 in TNBS group versus 5.25, 5.63, 5.13 and 3.25 in cinnamon oil groups). Our results confirmed that dietary administration of cinnamon oil could possess potential therapeutic effects on bacterial translocation and intestinal wall injury in colitis.
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