The function and architecture of DEAH/RHA helicases

Yangzi He, Gregers R. Andersen,  and Klaus H. Nielsen
  • 1 Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark
  • 2 Center for mRNP Biogenesis and Metabolism, Aarhus University, C.F. Møllers Allé 3, DK-8000 Aarhus C, Denmark

Abstract

Helicases are ubiquitous enzymes that participate in every aspect of nucleic acid metabolism. The DEAH/RHA family of helicases are involved in a variety of cellular processes including transcriptional and translational regulation, pre-mRNA splicing, pre-rRNA processing, mRNA export and decay, in addition to the innate immune response. Recently, the first crystal structures of a DEAH/RHA helicase unveiled the unique structural features of this helicase family. These structures furthermore illuminate the molecular mechanism of these proteins and provide a framework for analysis of their interaction with nucleic acids, regulatory proteins and large macromolecular complexes.

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BioMolecular Concepts is a peer-reviewed journal fostering the integration of different fields of biomolecular research. The journal provides expert summaries and conclusive extensions of research data leading to new and original, testable hypotheses. Aspects of research that can promote related fields and lead to novel insight into biological mechanisms are of special interest.

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