Atrial natriuretic peptide and related peptides

Yoshihiro J. Akashi 1 , 1 , Jochen Springer 2 , 2 , Mitja Lainscak 3 , 3  and Stefan D. Anker 4 , 4
  • 1 Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany and Division of Cardiology, Department of internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
  • 2 Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany
  • 3 Division of Applied Cachexia Research, Department of Cardiology, Charité Campus Virchow-Klinikum, Berlin, Germany and Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia
  • 4 Division of Applied Cachexia Research, Department of Cardiology, Charité Campus Virchow-Klinikum, Berlin, Germany and Department of Clinical Cardiology, National Lung and Heart Institute, Imperial College, London, UK

Abstract

In recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation. The well-known counter-regulatory hormones are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP) and urodilatin, which play an important role in the homeostasis of body fluid volume. ANP and BNP have already been demonstrated to have diagnostic usefulness in a great number of studies, which have progressed from bench to bedside. This article summarizes existing data on ANP and related peptides in cardiovascular and other disorders, and outlines the potential clinical usefulness of these markers.

Clin Chem Lab Med 2007;45:1259–67.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.

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