Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort

Hind Berrahmoune 1 , 1 , Bernard Herbeth 2 , 2 , John V. Lamont 3 , 3 , Daniel Lambert 4 , 4 , Stefan Blankenberg 5 , 5 , Laurence Tiret 6 , 6 , Peter S. FitzGerald 7 , 7 , Gérard Siest 8 , 8 ,  und Sophie Visvikis-Siest 9 , 9
  • 1 INSERM, U525, équipe 4, Nancy, France
  • 2 INSERM, U525, équipe 4, Nancy, France
  • 3 Randox Laboratories Ltd., Crumlin, Antrim, UK
  • 4 INSERM, U525, équipe 4, Nancy, France
  • 5 Department of Medicine II, Johannes Gutenberg-University Mainz, Mainz, Germany
  • 6 INSERM, U525, Paris, France
  • 7 Randox Laboratories Ltd., Crumlin, Antrim, UK
  • 8 INSERM, U525, équipe 4, Nancy, France and Université Henry Poincaré – Nancy I, Faculté de Pharmacie, Nancy, France
  • 9 INSERM, U525, équipe 4, Nancy, France


Background: Although high-sensitivity C-reactive protein (hs-CRP) has emerged as a cardiovascular marker, questions arise regarding the relative information provided by other inflammatory molecules. Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults.

Methods: Circulating concentrations of hs-CRP, haptoglobin, orosomucoid, interleukin-6 (IL-6), IL-8, IL-18, tumor necrosis factor-α (TNF-α), TNF-receptor II (TNF-RII), E-, P-, and L-selectins, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1, endothelial growth factor (EGF), vascular EGF (VEGF), insulin-like growth factor-1 (IGF-1) and IGF-binding protein (IGFBP-3) were measured in 154 men and 161 women of the Stanislas cohort. Leukocyte and platelet counts were also determined.

Results: Correlations were significant between hs-CRP concentrations and leukocyte and platelet counts, as well as haptoglobin, orosomucoid, IL-6, and ICAM-1 concentrations (p≤0.001). Correlation coefficients for ICAM-1 were higher in men than in women (p≤0.05). When stratifying subjects according to hs-CRP levels, the group with high hs-CRP levels had significantly higher haptoglobin and orosomucoid concentrations than the others, in addition to higher leukocyte counts and IL-6 concentrations in women, and platelet counts and ICAM-1 concentrations in men.

Conclusions: Further studies are warranted to explain the association pattern for hs-CRP. Partition of these factors according to their association with hs-CRP concentration opens a new perspective for choice of the best factors in terms of cardiovascular risk in relation to hs-CRP, while non-associated markers could be used to give additional information.

Clin Chem Lab Med 2007;45:1339–46.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over 3. CCLM is the official journal of 9 national clinical societies and associated with EFLM.