Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort

Hind Berrahmoune 1 , 1 , Bernard Herbeth 2 , 2 , John V. Lamont 3 , 3 , Daniel Lambert 4 , 4 , Stefan Blankenberg 5 , 5 , Laurence Tiret 6 , 6 , Peter S. FitzGerald 7 , 7 , Gérard Siest 8 , 8 ,  and Sophie Visvikis-Siest 9 , 9
  • 1 INSERM, U525, équipe 4, Nancy, France
  • 2 INSERM, U525, équipe 4, Nancy, France
  • 3 Randox Laboratories Ltd., Crumlin, Antrim, UK
  • 4 INSERM, U525, équipe 4, Nancy, France
  • 5 Department of Medicine II, Johannes Gutenberg-University Mainz, Mainz, Germany
  • 6 INSERM, U525, Paris, France
  • 7 Randox Laboratories Ltd., Crumlin, Antrim, UK
  • 8 INSERM, U525, équipe 4, Nancy, France and Université Henry Poincaré – Nancy I, Faculté de Pharmacie, Nancy, France
  • 9 INSERM, U525, équipe 4, Nancy, France


Background: Although high-sensitivity C-reactive protein (hs-CRP) has emerged as a cardiovascular marker, questions arise regarding the relative information provided by other inflammatory molecules. Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults.

Methods: Circulating concentrations of hs-CRP, haptoglobin, orosomucoid, interleukin-6 (IL-6), IL-8, IL-18, tumor necrosis factor-α (TNF-α), TNF-receptor II (TNF-RII), E-, P-, and L-selectins, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1, endothelial growth factor (EGF), vascular EGF (VEGF), insulin-like growth factor-1 (IGF-1) and IGF-binding protein (IGFBP-3) were measured in 154 men and 161 women of the Stanislas cohort. Leukocyte and platelet counts were also determined.

Results: Correlations were significant between hs-CRP concentrations and leukocyte and platelet counts, as well as haptoglobin, orosomucoid, IL-6, and ICAM-1 concentrations (p≤0.001). Correlation coefficients for ICAM-1 were higher in men than in women (p≤0.05). When stratifying subjects according to hs-CRP levels, the group with high hs-CRP levels had significantly higher haptoglobin and orosomucoid concentrations than the others, in addition to higher leukocyte counts and IL-6 concentrations in women, and platelet counts and ICAM-1 concentrations in men.

Conclusions: Further studies are warranted to explain the association pattern for hs-CRP. Partition of these factors according to their association with hs-CRP concentration opens a new perspective for choice of the best factors in terms of cardiovascular risk in relation to hs-CRP, while non-associated markers could be used to give additional information.

Clin Chem Lab Med 2007;45:1339–46.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.