The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects

Kazuhiko Kotani 1 , Naoki Sakane 2 , Kyoko Saiga 3 , Kokoro Tsuzaki 4 , Hisashi Shimohiro 5 , Masahiko Tabata 6 ,  and Youichi Kurozawa 7
  • 1 Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan and Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • 2 Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • 3 Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan
  • 4 Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • 5 Department of Clinical Laboratory, Tottori University Hospital, Yonago, Japan
  • 6 Department of Medicine, Ieshima Public Clinic, Hyogo, Japan
  • 7 Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan

Abstract

Background: The possible effects of the uncoupling protein-1 (UCP-1) gene −3826A/G polymorphism on hypertension (HT) have yet to be elucidated.

Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the −3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.

Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08–1.13)] and BMI [OR 1.13 (1.06–1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08–4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00–3.57)] was also an independent significant factor for HT in the relatively older subgroup (≥60 years).

Conclusions: The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.

Clin Chem Lab Med 2007;45:1186–9.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.

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