The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis

Christina Cimenti, Wolfgang Erwa 3 , Kurt R. Herkner 4 , David C. Kasper 4 , Wilhelm Müller 2 ,  and Bernhard Resch 1
  • 1 Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria
  • 2 Division of Neonatology, Department of Pediatrics, Medical University of Graz, Graz, Austria
  • 3 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
  • 4 Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria


Background: To determine the predictive value of the immature granulocyte count and the immature myeloid information in neonatal early onset sepsis we examined 133 blood samples of patients admitted to our neonatal intensive care unit.

Methods: Measurements were performed using the Sysmex XE-2100, an automated hematological analyzer. Patients were divided into two groups: 1) symptomatic neonates with diagnosis of early onset sepsis; and 2) controls including asymptomatic neonates who were admitted because of prematurity, low birth weight, or delayed postnatal transition.

Results: The number of immature granulocytes and the immature myeloid information were significantly elevated in neonates with early onset sepsis compared to controls (median 280/μL vs. 50/μL, p=0.049 and 639/μL vs. 89/μL, p<0.0001, respectively).

Conclusions: Automated determinations of immature granulocytes and immature myeloid information seem to be useful adjunctive methods in the diagnosis of neonatal early onset sepsis.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.