Falsely elevated cobalamin concentration in multiple assays in a patient with pernicious anemia: a case study

André P. van Rossum 1 , L. Thomas Vlasveld 2  and Ad Castel 1
  • 1 Department of Clinical Chemistry and Hematology, Bronovo Hospital, Bronovolaan The Hague, The Netherlands
  • 2 Department of Internal Medicine, Bronovo Hospital, Bronovolaan The Hague, The Netherlands
André P. van Rossum, L. Thomas Vlasveld and Ad Castel

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    Vlasveld LT, van’t Wout JW, Meeuwissen P, Castel A. High measured cobalamin (vitamin B12) concentration attributable to an analytical problem in testing serum from a patient with pernicious anemia. Clin Chem 2006;52:157–8.

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    Maugh K. High measured cobalamin (vitamin B12) concentration attributable to an analytical problem in testing serum from a patient with pernicious anemia: reply. Clin Chem 2006;52:158–9.

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    Carmel R, Brar S, Agrawal A, Penha PD. Failure of assay to identify low cobalamin concentrations. Clin Chem 2000;46:2017–8.

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    Carmel R, Agrawal YP. Failures of cobalamin assays in pernicious anemia. N Engl J Med 2012;367:385–6.

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    Heil SG, de Jonge R, de Rotte MC, van Wijnen M, Heiner-Fokkema RM, Kobold AC, et al. Screening for metabolic vitamin B12 deficiency by holotranscobalamin in patients suspected of vitamin B12 deficiency: a multicentric study. Ann Clin Biochem 2012;49:184–9.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.

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