Enzymatic isotope dilution mass spectrometry (IDMS) traceable serum creatinine is preferable over Jaffe in neonates and young infants

Karel Allegaert 1 , Steven Pauwels, Anne Smits, Kaat Crèvecoeur, John van den Anker, Djalila Mekahli and Pieter Vermeersch
  • 1 Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
  • 2 Department of Development and Regeneration, KU Leuven, Belgium
  • 3 Clinical Department of Laboratory Medicine, University Hospitals Leuven, Belgium
  • 4 Department of Cardiovascular Sciences, KU Leuven, Belgium
  • 5 Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, Washington, DC, USA
  • 6 Departments of Pediatrics, Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
  • 7 Pediatric Intensive Care, Erasmus MC Sophia Children’s Hospital, Rotterdam, The Netherlands
  • 8 Department of Paediatric Nephrology, University Hospitals Leuven, Leuven, Belgium
Karel Allegaert, Steven Pauwels, Anne Smits, Kaat Crèvecoeur, John van den Anker, Djalila Mekahli and Pieter Vermeersch

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1.

    Vieux R, Hascoet JM, Merdariu D, Fresson J, Guillemin F. Glomerular filtration rate reference values in very preterm infants. Pediatrics 2010;125:e1186–92.

  • 2.

    Allegaert K, Kuppens M, Mekahli D, Levtchenko E, Vanstapel F, Vanhole C, et al. Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method. J Matern Fetal Neonatal Med 2012;25:1678–81.

  • 3.

    Delanghe JR, Cobbaert C, Harmoinen A, Jansen R, Laitinen P, Panteghini M. Focusing on the clinical impact of standardization of creatinine measurements: a report by the EFCC Working Group on creatinine standardization. Clin Chem Lab Med 2011;49:977–82.

  • 4.

    Ceriotti F, Boyd JC, Klein G, Henny J, Queralto J, Kairisto V, et al. Reference intervals for serum creatinine concentrations: assessment of available data for global application. Clin Chem 2008;54:559–66.

  • 5.

    Ceriotti F. Establishing pediatric reference intervals: a challenging task. Clin Chem 2012;58:808–10.

  • 6.

    U.S. Department of Health and Human Services. About NKDEP. Available from: http://nkdep.nih.gov/about-nkdep/working-groups/laboratory-working-group.shtml. Accessed on 1 December, 2013.

  • 7.

    Greenberg N, Roberts WL, Bachmann LM, Wright EC, Dalton RN, Zakowski JJ, et al. Specificity characteristics of 7 commercial creatinine measurement procedures using enzymatic and Jaffe Method Principles. Clin Chem 2012;58:391–401.

  • 8.

    Peake M, Whiting M. Measurement of serum creatinine – current status and future goals. Clin Biochem Rev 2006;27:173–84.

  • 9.

    Crocker H, Shephard MD, White GH. Evaluation of an enzymatic method for determining creatinine in plasma. J Clin Pathol 1988;41:576–81.

  • 10.

    Allegaert K, Vanhaesebrouck S, Verbesselt R, van den Anker JN. In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age. Ther Drug Monit 2009;31:411–5.

Purchase article
Get instant unlimited access to the article.
$42.00
Log in
Already have access? Please log in.


Journal + Issues

Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.

Search