Mean corpuscular volume levels and all-cause and liver cancer mortality

Hyung-Jin Yoon 1 , Kyaehyung Kim 2 , You-Seon Nam 2 , Jae-Moon Yun 2 , and Minseon Park 2
  • 1 Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea
  • 2 Department of Family Medicine, Center for Health Promotion, Seoul National University Hospital, Seoul, Korea
Hyung-Jin Yoon, Kyaehyung Kim, You-Seon Nam, Jae-Moon Yun and Minseon Park

Abstract

Background: An elevated mean corpuscular volume (MCV) is associated with aging, nutrition, alcohol abuse and more, and it is known as a survival predictor in chronically ill patients. The aim of this study was to investigate the association between MCV levels and mortality from all-causes, cancer and site-specific cancer in a non-anemic healthy population.

Methods: A total of 36,260 participants aged 40 years or older who underwent routine check-ups at Seoul National University Hospital Health Promotion Center between 1995 and 2008 were followed-up for mortality until December 31, 2008, retrospectively.

Results: During an average follow-up of 8.0 years, 1107 deaths including 547 cancer deaths were observed. The adjusted hazard ratios (aHRs) of the subjects with the highest quartile of MCV ≥95.8 fL in men and MCV ≥94.2 fL in women for all-cause and cancer mortality were 1.44 [95% confidence interval (CI), 1.15–1.80] and 1.51 (95% CI, 1.10–2.07) for men and 1.55 (95% CI, 1.08–2.22) and 1.25 (95% CI, 0.74–2.11) for women, respectively, compared with those in the reference group (90.5 fL≤MC <93.0 fL in men and 89.2 fL≤MCV<91.6 fL in women). Elevated MCV level was related to an increased risk of liver cancer mortality in men (aHR, 3.55; 95% CI, 1.75–7.21).

Conclusions: This study suggests that the elevated MCV level in non-anemic cancer-free individuals was associated with increased all-cause mortality in both men and women, and with cancer mortality, in particular liver cancer mortality in men. Future prospective studies are required to consolidate our findings.

  • 1.

    Myojo M, Iwata H, Kohro T, Sato H, Kiyosue A, Ando J, et al. Prognostic implication of macrocytosis on adverse outcomes after coronary intervention. Atherosclerosis 2012;221:148–53.

    • Crossref
    • PubMed
    • Export Citation
  • 2.

    Japanese Society for Dialysis Therapy (JSDT). Guideline for renal anemia in chronic kidney disease. Toseki Kai-shi 2008;41:661–716.

  • 3.

    Joyce K, Cheryl ES. Evaluation of macrocytosis. Am Fam Physician 2009;79:203–8.

    • PubMed
    • Export Citation
  • 4.

    Yokoyama A, Yokoyama T, Muramatsu T, Omori T, Matsushita S, Higuchi S, et al. Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 2003;24:1773–8.

    • Crossref
    • PubMed
    • Export Citation
  • 5.

    Tennankore KK, Soroka SD, West KA, Kiberd BA. Macrocytosis may be associated with mortality in chronic hemodialysis patients: a prospective study. BMC Nephrol 2011;12:19.

    • Crossref
    • PubMed
    • Export Citation
  • 6.

    Ko YJ, Kwon YM, Kim KH, Choi HC, Chun Sh, Yoon HJ, et al. High-sensitivity C-reactive protein levels and cancer mortality. Cancer Epidemiol Biomarkers Prev 2012;21:2076–86.

    • Crossref
    • PubMed
    • Export Citation
  • 7.

    Solak Y, Yilmaz MI, Saglam M, Demirbas S, Verim S, Unal HU, et al. Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease. Nephrology (Carlton) 2013;18:728–35.

    • Crossref
    • PubMed
    • Export Citation
  • 8.

    Mena S, Ortega A, Estrela JM. Oxidative stress in environmental-induced carcinogenesis. Mutat Res 2009;674:36–44.

    • Crossref
    • PubMed
    • Export Citation
  • 9.

    Tsantes AE, Bonovas S, Travlou A, Sitaras NM. Redox imbalance, macrocytosis, and RBC homeostasis. Antioxid Redox Signal 2006;8:1205–16.

    • Crossref
    • PubMed
    • Export Citation
  • 10.

    Skjelbakken T, Lappegård J, Ellingsen TS, Barrett-Connor E, Brox J, Løchen ML, et al. Red cell distribution width is associated with incident myocardial infarction in a general population: the Tromsø Study. J Am Heart Assoc 2014;3:1–10.

  • 11.

    Mohanty JG, Nagababu E, Rifkind JM. Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging. Front Physiol 2014;5:84.

    • PubMed
    • Export Citation
  • 12.

    Kahraman S, Yilmaz R, Akinci D, Arici M, Altun B, Erdem Y, et al. U-shaped association of body mass index with inflammation and atherosclerosis in hemodialysis patients. J Ren Nutr 2005;15:377–86.

    • Crossref
    • PubMed
    • Export Citation
  • 13.

    Sánchez-Lara K, Turcott JG, Juárez E, Guevara P, Núñez-Valencia C, Oñate-Ocaña LF, et al. Association of nutrition parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study. Nutr Cancer 2012;64:526–34.

    • Crossref
    • PubMed
    • Export Citation
  • 14.

    Bérard E, Bongard V, Dallongeville J, Arveiler D, Ruidavets JB, Ferrières J, et al. Cancer mortality according to lipid-lowering drugs and lipoproteins in a general population. Curr Med Res Opin 2011;27:1963–71.

    • Crossref
    • Export Citation
  • 15.

    Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010;42:(Suppl 3):S206–14.

    • Crossref
    • PubMed
    • Export Citation
  • 16.

    National Statistical Office [internet]. Seoul, Korea. 2008 Annual report on the cause of death statistics (based on vital registration). [cited Dec 2014] Available from: http://www.nso.go.kr/.

  • 17.

    Chuang SC, La Vecchia C, Boffetta P. Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett 2009;286:9–14.

    • Crossref
    • PubMed
    • Export Citation
  • 18.

    Yeo Y, Gwack J, Kang S, Koo B, Jung SJ, Dhamala P, et al. Viral hepatitis and liver cancer in Korea: an epidemiological perspective. Asian Pac J Cancer Prev 2013;14:6227–31.

    • Crossref
    • PubMed
    • Export Citation
  • 19.

    Cardin R, Piciocchi M, Bortolami M, Kosafti A, Barzon L, Lavezzo E, et al. Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway. World J Gastroenterol 2014;20:3078–86.

    • Crossref
    • PubMed
    • Export Citation
  • 20.

    La Vecchia C, Lucchini F, Franceschi S, Negri E, Levi F. Trends in mortality from primary liver cancer in Europe. Eur J Cancer 2000;36:909–15.

    • Crossref
    • PubMed
    • Export Citation
Purchase article
Get instant unlimited access to the article.
$42.00
Log in
Already have access? Please log in.


or
Log in with your institution

Journal + Issues

Search