Interference of anticoagulants on coagulation testing

Daan van de Kerkhof, Ellen Schmitz, Mitchel Moolenaar 1 , Mark Schellings 4 , Arjen-Kars Boer, and Kristel Boonen 5
  • 1 Catharina Hospital Eindhoven, Clinical Laboratory, Eindhoven, The Netherlands
  • 2 Expert Center Clinical Chemistry Eindhoven, Eindhoven, The Netherlands
  • 3 Laboratory of Chemical Biology, Eindhoven University of Technology, Eindhoven, The Netherlands
  • 4 Maasstad Hospital, Department of Clinical Chemistry, Eindhoven, The Netherlands
  • 5 Amphia Hospital, Clinical Laboratory, Breda, The Netherlands
Daan van de Kerkhof, Ellen Schmitz, Mitchel Moolenaar, Mark Schellings, Arjen-Kars Boer and Kristel Boonen

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  • 1.

    Schmitz EM, Boonen K, van den Heuvel DJ, van Dongen JL, Schellings MW, Emmen JM, et al. Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants. J Thromb Haemost 2014;12:1636–46.

    • Crossref
    • PubMed
    • Export Citation
  • 2.

    Armbruster DA, Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev 2008;29(S1):S49–52.

    • PubMed
    • Export Citation
  • 3.

    Douxfils J, Tamigniau A, Chatelain B, Goffinet C, Dogné J-M, Mullier F. Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays. Thromb J 2014;12:24.

    • Crossref
    • PubMed
    • Export Citation
  • 4.

    Cuker A, Siegal DM, Crowther MA, Garcia DA. Laboratory measurement of the anticoagulant activity of the non-vitamin K oral anticoagulants. J Am Coll Cardiol 2014;64:1128–39.

    • Crossref
    • PubMed
    • Export Citation
  • 5.

    Garcia DA, Baglin TP, Weitz JI, Samama MM. Parenteral anticoagulants: antithrombotic therapy and prevention of thrombosis, 9th ed. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e24S–43S.

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