Plasminogen activator inhibitor-1 as a marker of cardiovascular response in professional mountain ultra-marathon runners

Giovanni Lombardi 1 , Gianluca Vernillo 2 , 3 , 4 , Veronica Sansoni 1 , Silvia Perego 1 , Andrea Barbuti 5 , 6 , Giampiero Merati 2 , 7 , Federico Schena 3 , 8 , Giuseppe Banfi 1 , 9  and Antonio La Torre 2
  • 1 Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
  • 2 Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
  • 3 CeRiSM, Research Centre “Sport, Mountain and Health”, Università degli Studi di Verona, Rovereto, Italy
  • 4 Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada
  • 5 Department of Biosciences, Università degli Studi di Milano, Milan, Italy
  • 6 Interuniversity Centre for Molecular Medicine and Applied Biophysics (CIMMBA), Università degli Studi di Milano, Milan, Italy
  • 7 IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
  • 8 Deptartment of Neurological and Movement Sciences, Università degli Studi di Verona, Verona, Italy
  • 9 Vita-Salute San Raffaele University, Milan, Italy
Giovanni Lombardi, Gianluca Vernillo, Veronica Sansoni, Silvia Perego, Andrea Barbuti, Giampiero Merati, Federico Schena, Giuseppe Banfi and Antonio La Torre

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  • 1.

    Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med 2012;10:77.

  • 2.

    Yamamoto K, Takeshita K, Saito H. Plasminogen activator inhibitor-1 in aging. Semin Thromb Hemost 2014;40:652–9.

  • 3.

    American College of Sports Medicine. ACSM’s Guidelines for Exercise Testing and Prescription, 8th ed. Philadephia, PA: Wolters Kluwer/Lippincott Williams & Wilkins, 2010.

  • 4.

    Galliera E, Lombardi G, Marazzi MG, Grasso D, Vianello E, Pozzoni R, et al. Acute exercise in elite rugby players increases the circulating level of the cardiovascular biomarker GDF-15. Scand J Clin Lab Invest 2014;74:492–9.

  • 5.

    Corsetti R, Lombardi G, Barassi A, Lanteri P, Colombini A, Melzi d’Eril G, et al. Cardiac indexes, cardiac damage biomarkers and energy expenditure in professional cyclists during the Giro d’Italia 3-weeks stage race. Biochem Med 2012;22:237–46.

  • 6.

    Lippi G, Cervellin G, Banfi G, Plebani M. Cardiac troponins and physical exercise. It’s time to make a point. Biochem Med 2011;21:55–62.

  • 7.

    Eijsvogels TM, Molossi S, Lee DC, Emery MS, Thompson PD. Exercise at the Extremes: the amount of exercise to reduce cardiovascular events. J Am Coll Cardiol 2016;67:316–29.

  • 8.

    Lippi G, Schena F, Salvagno GL, Montagnana M, Gelati M, Tarperi C, et al. Influence of a half-marathon run on NT-proBNP and troponin T. Clin Lab 2008;54:251–4.

  • 9.

    Banfi G, Lippi G, Susta D, Barassi A, D’Eril GM, Dogliotti G, et al. NT-proBNP concentrations in mountain marathoners. J Strength Cond Res 2010;24:1369–72.

  • 10.

    Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H. Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. Cardiovasc Res 2005;66:276–85.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.