Non-linearity in commercially available lipase assays: still gaps to close

Matthijs Oyaert 1 , Joris Delanghe 2 , Jan Van den Bossche 3 , Timothy Ghys 4  and Veronique Stove 2
  • 1 Department of Laboratory Medicine, Ghent University Hospital, C. Heymanslaan 10, Ghent 9000, Belgium
  • 2 Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
  • 3 Department of Laboratory Medicine, Antwerp University Hospital, Antwerp, Belgium
  • 4 Department of Laboratory Medicine, AZ Sint-Lucas, Ghent, Belgium
Matthijs Oyaert
  • Corresponding author
  • Department of Laboratory Medicine, Ghent University Hospital, C. Heymanslaan 10, Ghent 9000, Belgium
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, Joris Delanghe, Jan Van den Bossche, Timothy Ghys and Veronique Stove

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  • 1.

    Vogel AN, Goldsmith BM, Marzinke MA, Sokoll LJ, Stickle DF. Non-linearity within the primary measurement range of a lipase assay as the cause of a gap in the interpatient lipase results distribution. Clin Biochem 2016;49:176–9.

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  • 2.

    Roche Cobas 8000 lipase colorimetrix assay, package insert v2 (Feb 2018).

  • 3.

    Cattoir L, Pede V, Decavele AS, De Buyzere ML, Speeckaert MM, Seccombe D, et al. Influence of physical properties of cuvette surface on measurement of serum lipase. Clin Chem Lab Med 2013;51:2109–14.

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  • 4.

    Tietz NW, Shuey DF. Lipase in serum – the elusive enzyme: an overview. Clin Chem 1993;39:746–55.

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    • PubMed
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  • 5.

    Sarda L, Desnuelle P. Action de la lipase pancréatique sur les esters en émulsion. Biochim Biophys Acta 1958;30:513–21.

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Clinical Chemistry and Laboratory Medicine ( CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor of over three. CCLM is the official journal of nine national clinical societies and associated with EFLM.