Pore size estimation from double diffusion encoding

A multidimensional acquisition helps reduce numerical inversion instability

Vincent Methot 1 , Patricia Ulloa 1 ,  and Martin A. Koch 1
  • 1 Institute of Medical Engineering, University of Luebeck, Ratzeburger Allee 160, 23562 Lübeck, Germany

Abstract

Double diffusion encoding is a magnetic resonance technique with applications in measuring microstructure. In many tissues, cell size (which is of a few micrometers) is an important biological parameter. Estimating an arbitrary pore size distribution from a diffusion attenuated signal usually relies on varying a single experimental setting. This inversion process is numerically unstable. Numerical simulations are presented, where multiple experimental settings are varied concomitantly. The inversion’s results show good agreement with ground truth.

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Current Directions in Biomedical Engineering is an open access journal and closely related to the journal Biomedical Engineering - Biomedizinische Technik. CDBME is a forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering for medicine and addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.

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