Polymer drug release system for biofilm inhibition in medical application

Katharina Wulf 1 , Daniela Arbeiter 2 , Thomas Eickner 2 , Katharina Riedel 3 , Klaus-Peter Schmitz 4 , Niels Grabow 2  and Stefanie Kohse 2
  • 1 University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich- Barnewitz-Str. 4, D-18119, Rostock, Germany
  • 2 University Medical Center Rostock, Institute for Biomedical Engineering,, Rostock, Germany
  • 3 Ernst-Moritz-Arndt-University of Greifswald, Department of Microbial Physiology and Molecular Biology,, Greifswald, Germany
  • 4 University Medical Center Rostock, Institute for Biomedical Engineering, Rostock, Germany and Institute for Implant Technology and Biomaterials e.V.,, Rostock, Germany


Bacterial biofilm formation on surfaces is still a critical challenge regarding the application of implants. Generally, in order to avoid this, an additional systemic administration of antibiotics is given, which can lead to side effects, such as the reduction of the intestinal flora. Continuous treatment may lead to antibiotics resistance. Within this study we investigated the local drug delivery of N-acetyl-L-cysteine (NAC) from a Poly-L-lactide (PLLA) coating, an ished biodegradable polymer and a polyetherurethane (PEU) coating, a promising representative non-degradable polymer for cardiovascular applications as alternative to the administration of antibiotics. The incorporation of NAC influenced the surface properties of PEU in contrast to that of PLLA. The in vitro NAC release is almost completed after 24 h for PEU. For PLLA only small amounts of incorporated NAC, depending on the NAC loading, is released after a short time. Both systems are rather useful as local NAC delivery system directly after implantation.

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Journal + Issues

Current Directions in Biomedical Engineering is an open access journal and closely related to the journal Biomedical Engineering - Biomedizinische Technik. CDBME is a forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering for medicine and addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.