Louis Lapicque introduced the hyperbolic stimulation law with the key parameters “rheobase” and “chronaxie” that were obtained with rectangular current pulses. With rectangular pulses rheobase cannot be measured. It was found recently that hyperbolic stimulation rules are also valid for non-rectangular pulses and that their rheobase or chronaxie values are identical with that of their rectangular counterparts. Threshold measuring with exponential pulses allow for determining rheobase directly and chronaxie by calculation with only two measurements. The measuring procedure is described in detail.
Current Directions in Biomedical Engineering is an open access journal and closely related to the journal
Biomedical Engineering - Biomedizinische Technik.CDBME is a forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering for medicine and addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.