Intervention assessment tool for primary tumors in the liver

Cristina Laura Oyarzun 1 , Klaus Drechsler 2 , Marius Erdt 3 , Stefan Wesarg 4  and Reto Bale 5
  • 1 Fraunhofer IGD and Technische Universität Darmstadt, Fraunhoferstrasse 5,, Darmstadt, Germany
  • 2 Aachen University of Applied Sciences,, Aachen, Germany
  • 3 Fraunhofer IDM@NTU,, Singapore, Singapore
  • 4 Fraunhofer IGD, Fraunhoferstrasse 5,, Darmstadt, Germany
  • 5 University Clinic of Radiology, Innsbruck Medical University,, Innsbruck, Austria


After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm.

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Current Directions in Biomedical Engineering is an open access journal and closely related to the journal Biomedical Engineering - Biomedizinische Technik. CDBME is a forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering for medicine and addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.