Measuring of calcification risk with polymer microchips

Julia Bavendiek 1 , Johannes Sackmann 2 , Werner Karl Schomburg 2 , Steffen Gräber 3 , Wilhelm Jahnen-Dechent 4  und Andreas Pasch 5
  • 1 Lehr- und Forschungsgebiet Konstruktion und Entwicklung von Mikrosystemen (KEmikro), RWTH Aachen, Campus-Boulevard 30, 52074, Aachen, Germany
  • 2 Forschungsgebiet Konstruktion und Entwicklung von Mikrosystemen (KEmikro), RWTH Aachen, Campus-Boulevard 30, 52074, Aachen, Germany
  • 3 Helmholtz-Institut für Biomedizinische Technik – Zell- und Molekularbiologie an Grenzflächen Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
  • 4 Helmholtz-Institut für Biomedizinische Technik – Zell- und Molekularbiologie an Grenzflächen Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany
  • 5 Calciscon AG, Aarbergstrasse 5, 2560, Nidau, Switzerland

Abstract

It has been shown that the formation of calcium phosphate crystals can be detected in patient blood using a polymer microchip manufactured by ultrasonic processing. Ultrasonic processing is recently evolving for the fabrication of low-cost microfluidic devices from thermoplastic polymers. The formation of calcium phosphate crystals can be measured in the blood serum of a patient both optically from a change in turbidity or in electrical resistance.

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Current Directions in Biomedical Engineering is an open access journal and closely related to the journal Biomedical Engineering - Biomedizinische Technik. CDBME is a forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering for medicine and addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.

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