Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications

Georgeta Voicu 1 , Alina Bădănoiu 1 , Ecaterina Andronescu 1 , and Carmen Chifiruc 2
  • 1 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
  • 2 Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 060101, Bucharest, Romania

Abstract

Materials for dental applications, i.e., white mineral trioxide aggregate (WMTA) and partial stabilized cements (PSC) were obtained using the sol-gel method. The presence of ZnO or/and CaF2 additions in the starting mixture induced changes in the composition, morphology and grindability of PSCs as compared with WMTA. The presence of foreign elements (Zn or F) in the crystalline lattice of mineralogical phases, increased their grindability. Thermal analysis (TG&DTA) was used to assess the kinetics of hydration process in binding systems based on WMTA/PSCs. The presence of foreign elements in PSCs systems increases the reactivity vs. water of these materials and consequently, the compressive strength developed after 28 days of hardening at 37°C are higher as compared with WMTA. The in vitro bioevaluation results (trypan blue staining, eukaryotic cells cycle assay by flowcytometry) accounted for a high biocompatibilty of the obtained materials demonstrating their potential use for biomedical applications.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • [1] M. Torabinejad, T.F. Watson, T.R. Pitt Ford, J. Endod. 19, 591 (1993) http://dx.doi.org/10.1016/S0099-2399(06)80271-2

  • [2] S.J. Lee, M. Monsef, M. Torabinejad, J. Endod. 19, 541 (1993) http://dx.doi.org/10.1016/S0099-2399(06)81282-3

  • [3] J. Camilleri et al., Dent. Mater. 21, 297 (2005) http://dx.doi.org/10.1016/j.dental.2004.05.010

  • [4] H.W. Roberts, J.M. Toth, D.W. Berzis, D.G. Charlton, Dent. Mater. 24, 149 (2008) http://dx.doi.org/10.1016/j.dental.2007.04.007

  • [5] F.H. Lin, W.H. Wang, C.P. Lin, Biomaterials 24, 219 (2003) http://dx.doi.org/10.1016/S0142-9612(02)00294-6

  • [6] T.R.P. Ford, D.J. McKendrey, Oral Surg. Oral Med. Oral Pathol. 79, 756 (1995) http://dx.doi.org/10.1016/S1079-2104(05)80313-0

  • [7] S.K. Vasudev, B.R. Goel, S. Tyagi, Endodont. 15, 12 (2003)

  • [8] S.J. Song, F.K. Mante, W.J. Romanov, S. Kim, OOOOE(Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.) 102, 809 (2006) http://dx.doi.org/10.1016/j.tripleo.2005.11.034

  • [9] H.F.W. Taylor, Cement Chemistry (Academic Press, London, 1997) http://dx.doi.org/10.1680/cc.25929

  • [10] M. Georgescu, A. Bădănoiu, Cement Concrete Comp. 19, 295 (1997) http://dx.doi.org/10.1016/S0958-9465(97)00021-8

  • [11] S. Asgary, M. Parirokh, M.J. Eghbal, S. Stone, F. Brink, J. Mater. Sci Mater. Med. 17, 187 (2006) http://dx.doi.org/10.1007/s10856-006-6823-3

  • [12] T. Dammaschke, H.U.V. Gerth, H. Züchner, E. Schäfer, Dent. Mater. 21, 731 (2005) http://dx.doi.org/10.1016/j.dental.2005.01.019

  • [13] D. Stephan, P. Wihelm, Z. Anorg. Allg. Chem. 630, 1477 (2004) http://dx.doi.org/10.1002/zaac.200400090

  • [14] G. Voicu, C.D. Ghiţulică, E. Dinu, E. Andronescu, Rev. Rom. Mater. 41, 229 (2011) http://dx.doi.org/10.1146/annurev-matsci-062910-100341

  • [15] G. Voicu, C.D. Ghiţulică, E. Andronescu, Mater. Characterization, 73, 89 (2012) http://dx.doi.org/10.1016/j.matchar.2012.08.002

  • [16] W-H. Wang, Y-L. Lee, C-P. Lin, F.-H. Lin, J. Biomed. Mater. Res. 85A, 964 (2008) http://dx.doi.org/10.1002/jbm.a.31532

  • [17] F. Ndong, S. Sadhasivam, F-H. Lin, S. Savitha, W-H. Wang, C-P. Lin, International Endod. J. 45, 557 (2012) http://dx.doi.org/10.1111/j.1365-2591.2012.02011.x

  • [18] G. Voicu, A.I Bădănoiu, C.D. Ghiţulică, E. Andronescu, Digest J. Nanomat. Biostruct. 7, 1639 (2012)

  • [19] G. Voicu, A.I. Bădănoiu, E. Andronescu, C. Bleotu, Rev. Chim. 63, 1031 (2012)

  • [20] W-H. Wang, F-H. Lin, Y-L. Lee, C-P. Lin, J. Biomed. Mater. Res. 81A, 195 (2007) http://dx.doi.org/10.1002/jbm.a.30919

  • [21] I. Teoreanu, T. van Huynh, S. Stoleriu, Rev. Roum. Chim. 48, 947 (2003)

  • [22] L. Kamici, A. Seimenon-Masseron, A. Ghomari, Z. Derriche, C.R. Chimie. 9, 154 (2006) http://dx.doi.org/10.1016/j.crci.2005.10.001

  • [23] H.U.V. Gerth, T. Dammaschke, E. Schafer, H. Zuchner, Dent. Mater. 23, 1521 (2007) http://dx.doi.org/10.1016/j.dental.2006.12.007

  • [24] H.T. Dean, Publ. Health. Rep. 53, 1443 (1938) http://dx.doi.org/10.2307/4582632

  • [25] Romanian Standard, SR EN 196-2:2006, Methods of testing cement — Part 2: Chemical analysis of cement (2006) (in Romanian)

  • [26] A.M. Grumezescu, A.M. Holban, E. Andronescu, A. Ficai, C. Bleotu, M.C. Chifiriuc, Lett. Appl. NanoBioScience. 1, 77 (2012)

  • [27] C. Saviuc, A.M. Grumezescu, C. Bleotu, A. Holban, C. Chifiriuc, P. Balaure, V. Lazar, Biointerface Res. in App. Chem. 1, 111 (2011)

  • [28] A.M. Grumezescu, E. Andronescu, A. Ficai, C. Bleotu, M.C. Chifiriuc, Biointerface Res. in App. Chem. 2, 438 (2012)

  • [29] O. Banu, C. Bleotu, M.C. Chifiriuc, B. Savu, G. Stanciu, C. Antal, M. Alexandrescu, V. Lazăr, Biointerface Res. in App. Chem. 1, 72 (2011)

  • [30] A. Bădănoiu, J. Paceagiu, G. Voicu, J. Therm. Anal. Calorim. 103, 879 (2011) http://dx.doi.org/10.1007/s10973-010-1125-x

  • [31] A. Migdal-Mikuli, J. Hetmanczyk, L. Hetmanczyk, J. Therm. Anal. Calorim. 89, 499 (2007) http://dx.doi.org/10.1007/s10973-006-7526-1

  • [32] H.P. Klug, L.E. Alexander, (Eds.), X-Ray Diffraction procedures for polycrystalline and amorphous materials (John Wiley and Sons, New York, 1974) 687

  • [33] L. Opoczy, V. Gavel, Int. J. Miner. Process. 74, S129 (2004) http://dx.doi.org/10.1016/j.minpro.2004.07.020

  • [34] W Strober, Current Protocols in Immunology, A.3B.1–A.3B.2 (2001)

OPEN ACCESS

Journal + Issues

Search