Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

Mariana Prodana 2 , Adriana Voiculet 2 , Sorina Garea 3 , Mihaela Radu 1 , Horia Iovu 3 , Ioana Demetrescu 2 , and Anca Dinischiotu 1
  • 1 University of Bucharest
  • 2 Polytechnic University of Bucharest
  • 3 Polytechnic University of Bucharest

Abstract

This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.

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