Simple synthesis of 3-acyl-5-alkyl(aryl)isoxazoles from terminal alkynes and nitrates of alkaline metals or ammonium

Victor Rogachev 1 , Victor Filimonov 1 , Julya Kulmanakova 2 , Mehman Yusubov 2 , and Wolfgang Bender 3
  • 1 Department of Organic Chemistry, Tomsk Polytechnic University, 634050, Tomsk, Russia
  • 2 Department of Chemistry, Siberian State Medical University, 634050, Tomsk, Russia
  • 3 Business Group Pharma, Research, Bayer AG, D-42096, Wuppertal, Germany

Abstract

A simple and general synthesis of 3-acyl-5-alkyl(aryl)isoxazoles by reaction of terminal alkynes with nitrates in acetic acid in the presence of SO3 or alkaline salts is described.

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