Palladium-catalyzed amination of quinaldine-5-triflate

Melinda Fekete 1 , Mercedesz Töröncsi 1 , and Lajos Novak 1
  • 1 Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Research Group for Alkaloid Chemistry, Hungarian Academy of Sciences, 1111, Budapest, Hungary

Abstract

Palladium-catalyzed amination reactions of quinoline triflate and the effect of a Pd catalyst, its ligands, solvents, bases, and temperature were studied. This method facilitated an easier pathway for the preparation of aminoquinoline derivatives as potential precursors of new serotoninerg agents.

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