Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water

Noora Kuuloja 1 , Tuula Kylmälä 1 , Youjun Xu 2 , and Robert Franzén 1
  • 1 Department of Chemistry and Bioengineering, Tampere University of Technology, 33101, Tampere, Finland
  • 2 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China

Abstract

Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively.

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