Plasma-chemical modifications of cellulose for biomedical applications

David Pavliňák 1 , Veronika Švachová 2 , Libor Vojtek 4 , Jana Zarzycká 4 , Pavel Hyršl 4 , Milan Alberti 1 ,  and Lucy Vojtová 3
  • 1 Department of Physical Electronics, Masaryk University, 61137 Brno, Czech Republic
  • 2 Faculty of Chemistry, Institute of Materials Chemistry, Brno University of Technology, 61200 Brno, Czech Republic
  • 3 CEITEC – Central European Institute of Technology, Brno University of Technology, 61600 Brno, Czech Republic
  • 4 Institute of Experimental Biology, Masaryk University, 61137 Brno, Czech Republic


A 6-carboxycellulose (in medicine known as “oxidized cellulose” or “oxycellulose”) is one of the cellulose derivatives popular in the field of surgery. Health products based on oxidized cellulose are great local hemostatics with unique bactericidal and fully bioabsorbable effects. Traditional process of native cellulose oxidation is described as a complex radical reaction in strong acidic liquid medium doped by toxic nitrous radicals (NO*). Our plasma-chemical reaction demonstrates a new synthesis method of oxidized cellulose with unique bactericidal effect. This plasma-chemical treatment is based on atmospheric plasma discharge in liquid medium leading to the oxidation of polysaccharide molecules resulting in oxycellulose. Final oxycellulose properties were evaluated by infrared spectroscopy and carboxyl content determination. The biological impact showed a strong germicidal effect.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • [1] Schonauer C., Tessitore E., Barbagallo G., Albanese V., Moraci A., Eur. Spine J., 13, Suppl. 2004, 10, S89

  • [2] Pendharkar S.M., Wissing W.W., European Patent Application EP1424087 A1, 2004.06.02

  • [3] Švachová V., Master’s thesis, Masaryk University, Brno, 2012

  • [4] Kumar V., Yang T., Carbohyd Polym., 2002, 48, 403

  • [5] Bajerova M., Krejcova K., Rabiskova M., Gajdziok J., Masteikova R., Adv. Polym. Tech., 2009, 28, 199

  • [6] Yackel E.C., Kenyon W.O., J. Am. Chem Soc., 1942, 64, 121

  • [7] Friedman A., Plasma Chemistry, Cambridge University Press, USA, 2008

  • [8] Atosuo J., Lehtinen J., Vojtek L., Liliu E.M.s, Luminescence, 2013, 28, 771

  • [9] Buchtikova S., Vetesnikova Simkova A., Rohlenova K., Flajshans M., Lojek A., Lilius E.M., Hyrsl P., Aquaculture, 2011, 318, 169

  • [10] Janča J., Klı́ma M., Slavı́ček P., Zajı́čková L., Surf. Coat. Tech., 1999, 116

  • [11] Janča J., Zajíčková L., Klíma M., Slavíček P., Plasma Chem. Plasma P, 2001, 21(4), 565

  • [12] United States Pharmacopeia (USP31)–NF26, p. 1702

  • [13] Wei L., Bingjie S., Peiyi W., Carbohyd. Polym., 2009, 78, 454


Journal + Issues

Open Chemistry is a peer-reviewed, open access journal that publishes original research, reviews and short communications in the fields of chemistry in an ongoing way. Our central goal is to provide a hub for researchers working across all subjects to present their discoveries, and to be a forum for the discussion of the important issues in the field.