Quantifying the Effects of Compound Combinations

Quantifying the Effects of Compound Combinations

As ever more combination therapies are applied in various areas of medicine, there is a growing need for quantitative descriptions of combination effects. While most of the scientific community has agreed on a basic standard for synergy, there is no consensus on quantifying the degree to which a combination may deviate from synergy, and no predictive models are accepted to serve as benchmarks.

This project will convene a working group, involving leading experts on combination effects, to (1) endorse the synergy criterion recommended at a recent meeting in Finland, (2) adopt standard measures of combination effect to quantify deviations from synergy, and (3) explore predictive combination-effect models for multiply-inhibited biological interaction networks.

For more information contact the Task Group Chairman Joseph Lehár <jlehar@combinatorx.com>.


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Chemistry International is the newsmagazine of the International Union of Pure and Applied Chemistry (IUPAC). News about IUPAC, its chemists, its publications, its recommendations, its conferences and the work of its commissions and committees is published bimonthly in CI.