Glossary of Terms Used in Toxicology, 2nd Edition (IUPAC Recommendations 2007)

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Glossary of Terms Used in Toxicology, 2nd Edition (IUPAC Recommendations 2007)

(IUPAC Recommendations 2007)

John H. Duffus, Monica Nordberg, and Douglas M. Templeton

Pure and Applied Chemistry

Vol. 79, No. 7, pp. 1153–1344, 2007


In 1993, the importance of toxicology to chemists was recognized by the publication in Pure and Applied Chemistry (PAC) of the “Glossary for Chemists of Terms Used in Toxicology.”1 This glossary has been widely accepted and used, but, inevitably, with the continuing development of both chemistry and toxicology, terms have changed their meanings as a result of altered usage and new terms have been coined. Further, some important terms were overlooked, notably those relating to toxico-kinetics, and a supplementary glossary has already been published in PAC.2 The revised and extended glossary presented here includes all new terms identified as relevant by the Working Party, together with those in toxicokinetics previously omitted. As before, the glossary is compiled primarily for chemists who now find themselves working in toxicology or requiring a knowledge of the subject. However, there are also many other scientists as well as regulators and managers who have to interpret toxicological information and need ready access to internationally accepted definitions of relevant terms in common use.

In order to make this a convenient one-stop glossary, the terms included in this glossary have come from a wide range of disciplines that contribute to toxicology. For some of the entries, alternative definitions are given in order to display the significant differences in their use that occur in practice. Many medical terms are included because of their frequent occurrence in the toxicological literature. There are three annexes, one containing a list of abbreviations and acronyms used in toxicology, one containing a list of abbreviations and acronyms used by international bodies and by legislation relevant to toxicology and chemical safety, and one describing the classification of carcinogenicity according to the weight of evidence available.

1. Pure Appl. Chem.65, 2003 (1993)

2. Pure Appl. Chem.76, 1033 (2004)

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