Adolescent suicide and testosterone

Postnatal testosterone may be an important mediator of the association between prematurity and male neurodevelopmental disorders: A Hypothesis

Timothy R. Rice 1  and Leo Sher 1
  • 1 Department of Psychiatry, New York, USA
Timothy R. Rice
  • Corresponding author
  • Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, USA
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and Leo Sher
  • Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, USA
  • Search for other articles:
  • degruyter.comGoogle Scholar


Completed suicide is much more common in men than in women. Its incidence rises precipitously in adolescence. One biological hypothesis that accounts for the increased frequency of completed suicide in men is that the male sex hormone testosterone partially mediates the observed increase in suicide frequency among men. It is the aim of this communication to review the relevant literature and to describe putative biological mechanisms for this association. Specifically, we propose that the impairment wrought by of high levels of testosterone in the adolescent upon the emotion regulation system contribute to an account for these findings. Herein, we describe this neural system and the specific effects of testosterone upon the system. We conclude with a discussion of clinical implications and applications with an aim of stimulating further research.

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The International Journal of Adolescent Medicine and Health ( IJAMH) provides an international and interdisciplinary forum for the dissemination of new information in the field of adolescence. IJAMH covers all aspects of adolescence. The International Editorial Board is dedicated to producing a high quality scientific journal of interest to researchers and practitioners from many disciplines.